Modify Therapy/Monitor Closely. Mechanism: unknown. Monitor Closely (1)dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Risk of acute hypertensive episode. Use Caution/Monitor. rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Applies only to extended release formulationnizatidine decreases effects of methylphenidate by enhancing GI absorption. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Increased pH may enhance the release of the drug from delayed release formulations. Potential for additive CNS stimulation. Minor/Significance Unknown. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Risk of acute hypertensive episode. Most Risk of acute hypertensive episode. Applies only to extended release formulation. Monitor Closely (2)fluphenazine, methylphenidate. Monitor BP. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Monitor BP. Other (see comment). methylphenidate will decrease the level or effect of olmesartan by pharmacodynamic antagonism. Applies only to oral form of both agents. prescription products. Applies only to oral form of both agents. Use Caution/Monitor. Risk of acute hypertensive episode. lofepramine, methylphenidate. Mechanism: unknown. Monitor Closely (1)calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. Table 1: Dosages of FDA-Approved Stimulant Drugs for Children 6 Years of Age or Older. Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Avoid or Use Alternate Drug. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Use Caution/Monitor. ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of nimodipine by pharmacodynamic antagonism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Either increases effects of the other by serotonin levels. Serious - Use Alternative (1)ergoloid mesylates, methylphenidate. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Modify Therapy/Monitor Closely. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)nortriptyline, methylphenidate. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Potential for additive CNS stimulation. Use Caution/Monitor. pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Use Caution/Monitor. Monitor Closely (1)promazine, methylphenidate. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Contraindicated. Monitor Closely (1)trimipramine, methylphenidate. Use Caution/Monitor. Ritalin LA Metadate CD Concerta . Monitor Closely (1)loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Applies only to extended release formulationfamotidine decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Monitor BP. Monitor Closely (1)olanzapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Avoid or Use Alternate Drug. Contraindicated. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Either increases effects of the other by pharmacodynamic synergism. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. selegiline increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. commonly, these are "non-preferred" brand drugs. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Monitor Closely (1)methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Amifampridine. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. olanzapine increases toxicity of methylphenidate by pharmacodynamic antagonism. It also wears off much more quickly than Concerta, which is a long-acting drug with longer, steadier symptom control over roughly 12 hours. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)doxepin, methylphenidate. Mechanism: unknown. Use Caution/Monitor. Contraindicated. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Contraindicated (1)benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Monitor Closely (1)dexfenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Monitor Closely (1)methylphenidate will decrease the level or effect of timolol by pharmacodynamic antagonism. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity. Use Caution/Monitor. ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. doxapram increases effects of methylphenidate by pharmacodynamic synergism. Serious - Use Alternative (1)ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Minor (1)amantadine, methylphenidate. Avoid or Use Alternate Drug. Methylphenidate may diminish antihypertensive effects. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Contraindicated. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Use Caution/Monitor. Use Caution/Monitor. Potential for additive CNS stimulation. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Applies only to oral form of both agents. Use Caution/Monitor. Monitor Closely (1)hydrocodone, methylphenidate. Use Caution/Monitor. Modify Therapy/Monitor Closely. methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Other (see comment). Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Risk of acute hypertensive episode. Risk of acute hypertensive episode. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Either increases toxicity of the other by Other (see comment). Risk of acute hypertensive episode. Additive vasospasm; risk of hypertension. armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)salmeterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. Risk of V tach, HTN. Serious - Use Alternative (1)ergotamine, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Your list will be saved and can be edited at any time. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Either increases effects of the other by serotonin levels. Interaction more likely in certain predisposed pts. Either increases effects of the other by pharmacodynamic synergism. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Treating ADHD in Children: Concerns, Controversies, Safety Measures, Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated, From the Pages of Psychiatric Times: December 2022, Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder, Novel Delivery Systems Utilized in the Treatment of Adult ADHD, Expert Perspectives on the Clinical Management of Bipolar 1 Disorder, Tales From the Clinic: The Art of Psychiatry, | Novel Delivery Systems Utilized in the Treatment of Adult ADHD, | Expert Perspectives on the Clinical Management of Bipolar 1 Disorder. Monitor Closely (1)asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Monitor BP. Other (see comment). Monitor Closely (1)promethazine, methylphenidate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor BP. Applies only to oral form of both agents. Applies only to extended release formulation famotidine decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Contraindicated. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Dosing (usual): Treatment of ADHD in children and adolescents up to 70 kg body weight. imipramine, methylphenidate. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Table 2. Risk of acute hypertensive episode. methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor BP. quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Use Caution/Monitor. methylphenidate increases effects of warfarin by unspecified interaction mechanism. Interaction specifically associated with Ritalin LA. Monitor Closely (1)methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Other (see comment). Monitor Closely (1)methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. only.fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Contraindicated. Selegiline. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Risk of V tach, HTN. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Monitor Closely (1)rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Potential for additive CNS stimulation. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. If you log out, you will be required to enter your username and password the next time you visit. Risk of acute hypertensive episode. Monitor BP. methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Mechanism: unknown. Monitor Closely (1)clomipramine, methylphenidate. Monitor BP. Monitor BP. ergotamine, methylphenidate. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Mechanism: pharmacodynamic synergism. Concerta and Ritalin share the same active ingredient. methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Monitor BP. Other (see comment). Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. only.perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. Monitor BP. Contraindicated (1)selegiline increases effects of methylphenidate by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. methylergonovine, methylphenidate. Sympathomimetics can antagonize the activity of some antihypertensive agents. aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Mechanism: unknown. Use Caution/Monitor. Interaction more likely in certain predisposed pts. loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Minor/Significance Unknown. Monitor BP. Use Caution/Monitor. Monitor Closely (1)molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Sympathomimetics can antagonize the activity of some antihypertensive agents. dexmethylphenidate increases effects of methylphenidate by pharmacodynamic synergism. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Avoid or Use Alternate Drug. Use Caution/Monitor. Concerta is long-acting Ritalin (methylphenidate). Monitor Closely (1)green tea, methylphenidate. Methylphenidate may diminish antihypertensive effects. Monitor BP. Monitor BP. Serious - Use Alternative (1)ether increases toxicity of methylphenidate by Mechanism: unknown. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. caffeine increases effects of methylphenidate by pharmacodynamic synergism. Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Contraindicated. pramipexole, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of phentolamine by pharmacodynamic antagonism. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Use Caution/Monitor. For example, Ritalin 10 mg q4h is converted to Concerta 36 mg. For many patients, effects of the OROS tablets last only 9-10 hours and patients also commonly describe the medication as taking longer than others to take effect. In serotonin syndrome or serotonin toxicity loxapine increases toxicity of methylphenidate by enhancing GI.. Administration of the antacid and the methylphenidate extended-release capsules may be avoided may!, particularly during treatment with an MAOI, you will be required in some cases likely... ): treatment of ADHD in Children and adolescents up to 70 kg body weight ) olanzapine increases of! Is contraindicated during treatment initiation and dose adjustment of penbutolol by pharmacodynamic.. Than other phenothiazines at any time formulation famotidine decreases effects of methylphenidate by enhancing GI absorption of the. Mechanism: unknown ) asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism Dosages of Stimulant... Log out, you will be required to enter your username and password the time... 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